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Month: October 2025

What NRX-100 and NRX-101 Could Mean for Suicide-Focused Depression Carement

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Suicidal ideation in major depressive disorder and bipolar depression remains a public health emergency, with U.S. deaths by suicide reaching historically high levels in recent years. Against this backdrop, NRx Pharmaceuticals has advanced two investigational agents that target this gap: NRX-100, a preservative-free intravenous ketamine, and NRX-101, an oral fixed-dose combination of D-cycloserine and lurasidone. Understanding how FDA pathways such as Fast Track and Accelerated Approval work, and where these programs may apply, helps clarify what patients, families, and clinicians might expect as development moves forward. Where NRX-100 and NRX-101 Fit Clinically NRX-100 is being studied for rapid relief of acute suicidal ideation in depression, including bipolar depression. Ketamine’s rapid antidepressant effect is well documented, but its clinical use has been limited by temporary benefit and the need for monitored infusion. A proprietary, preservative-free …

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How to Build Emotional Resilience for Mental Health

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Emotional resilience is the ability to adapt, recover, and even grow in the face of adversity. It does not mean avoiding stress or never feeling overwhelmed, but rather cultivating the capacity to navigate challenges in a healthier and more balanced way. Building resilience is essential for mental health, as it reduces vulnerability to depression, anxiety, and burnout while improving overall well-being. Fortunately, resilience is not a fixed trait—it can be developed through intentional practices and supportive environments. Understanding Emotional Resilience Resilience involves the interplay of biological, psychological, and social factors. People with higher resilience are better able to regulate emotions, maintain perspective, and access coping skills during difficult times. According to research in the Annual Review of Clinical Psychology, resilience is shaped by both genetic predispositions and learned behaviors. This means that even if …

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Understanding Anxiety Triggers and How to Manage Them

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Anxiety is a normal response to stress, but when it becomes overwhelming or persistent, it can interfere with daily life and well-being. Identifying and understanding the triggers that set off anxiety is an important step in managing symptoms. Triggers can be external, such as stressful environments or social pressures, or internal, such as intrusive thoughts or physical sensations. By recognizing these triggers and learning strategies to manage them, individuals can reduce the intensity of their anxiety and regain a greater sense of control. Common Anxiety Triggers Anxiety triggers vary from person to person, but several are frequently reported across clinical studies. Work-related stress, financial difficulties, health concerns, and interpersonal conflict are among the most common external triggers. Social situations, including public speaking or meeting new people, can provoke significant anxiety for individuals with social …

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The Role of Therapy in Treating Depression

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Depression is one of the most common and debilitating mental health conditions worldwide, affecting millions of people each year. While medication can play an important role in treatment, therapy is a cornerstone of effective depression care. Talk therapy provides a safe, structured environment for individuals to explore thoughts and emotions, develop coping strategies, and create long-term change. Research consistently shows that therapy not only alleviates symptoms but also reduces the risk of relapse, making it a vital tool in recovery. Understanding Depression and Its Impact Depression is more than just persistent sadness. It involves a range of symptoms such as fatigue, loss of interest in activities, sleep disturbances, appetite changes, difficulty concentrating, and feelings of worthlessness or hopelessness. Left untreated, it can interfere with work, relationships, and overall quality of life. According to the …

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How to Cope with Panic Attacks Effectively

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Panic attacks can be overwhelming, often striking suddenly with intense fear, physical discomfort, and a sense of losing control. While they are not life-threatening, the experience can feel terrifying and exhausting. Learning to recognize the signs and developing strategies to cope can help reduce their impact and prevent them from interfering with daily life. With proper management, many people find they can regain confidence and improve their overall quality of life. Recognizing the Symptoms of a Panic Attack Panic attacks typically involve a rapid onset of intense fear that peaks within minutes. Symptoms may include a racing heartbeat, sweating, trembling, chest pain, dizziness, shortness of breath, and a sense of impending doom. For some individuals, these symptoms mimic those of a heart attack, which can add to the distress. According to the National Institute …

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